Trimethylsilyl iodide → HCID 178511031、化合物
反応式
C(OC(=O)[NH:10][CH2:11][CH2:12][CH2:13][C@H:14]1[CH2:18][NH:17]/[C:16](=[N:19]\[C:20]([C:22]2[C:27]([NH2:28])=[N:26][C:25]([NH2:29])=[C:24]([Cl:30])[N:23]=2)=[O:21])/[NH:15]1)C1C=CC=CC=1.I[Si](C)(C)C>C(Cl)Cl>[NH2:10][CH2:11][CH2:12][CH2:13][C@H:14]1[CH2:18][NH:17]/[C:16](=[N:19]\[C:20]([C:22]2[C:27]([NH2:28])=[N:26][C:25]([NH2:29])=[C:24]([Cl:30])[N:23]=2)=[O:21])/[NH:15]1参加物
4
実験手順
To a solution of (3-{(S)-2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-imidazolidin-4-yl}-propyl)-carbamic acid benzyl ester (Ex. 30) (0.44 g, 0.98 mmol) in DCM (20 ml) is added iodotrimethylsilane (0.27 ml, 1.96 mmol) in a dropwise manner. The orange suspension is stirred at room temperature for 65 minutes. Purification by catch and release resin (SCX-2) eluting with MeOH followed by 7M NH3 in MeOH yields the title compound as a yellow foam; [M+H]+ 313.1