Potassium Carbonate → HCID 59633880、化合物

HRID 2365604ノート

反応式

HRID 2365604 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][C:4]=1F)#[N:2].[C:23]([O-])([O-])=[O:24].[K+].[K+]>CO.O>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:17]3[C:12](=[CH:13][C:14]([C:18]([O:20][CH3:21])=[O:19])=[CH:15][CH:16]=3)[CH:11]=[CH:10]2)=[CH:5][C:4]=1[O:24][CH3:23])#[N:2]

参加物

5

反応物 2

HCID 11430Potassium CarbonateHCID 59633877HCID 59633877、化合物

生成物 1

HCID 59633880HCID 59633880、化合物収率 102%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

A solution of 95 mg (0.32 mmol) of compound 9m was combined with 120 mg (0.87 mmol) of K2CO3 in 8 mL of MeOH and heated at 75° C. for 5 h. The mixture was cooled, diluted with water, and extracted with CH2Cl2. The organic solution was concentrated to give 100 mg (100%) of 9n as a white solid.

後処理

  1. temperatureThe mixture was cooled
  2. extractionextracted with CH2Cl2
  3. concentrationThe organic solution was concentrated

出典と根拠

ORDレコード
ord-c931f32d9b424d76801dd61ce4e84692
出典データセット
uspto-grants-2014_04
特許番号
US08697683B2

反応ノート

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