3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → HCID 46832293、化合物

反応式

[NH:1]([C:3]1[N:8]=[CH:7][C:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[CH:5][CH:4]=1)[NH2:2].O=[C:17]1[CH2:21][S:20][CH2:19][CH:18]1[C:22](OC)=[O:23]>>[O:23]=[C:22]1[N:1]([C:3]2[N:8]=[CH:7][C:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[CH:5][CH:4]=2)[NH:2][C:17]2[CH2:21][S:20][CH2:19][C:18]1=2

参加物

反応物 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester

HCID 45089857Tert-butyl 6-hydrazinylpyridine-3-carboxylate

生成物 1

HCID 46832293HCID 46832293、化合物収率 61.1%

実験手順

According to the process described in Example 1, starting with 0.75 g of tert-butyl 6-hydrazinopyridine-3-carboxylate and 0.58 g of methyl 4-oxotetrahydrothiophene-3-carboxylate, 0.7 g of tert-butyl 6-(3-oxo-4,6-dihydro-1H-thieno[3,4-c]pyrazol-2(3H)-yl)pyridine-3-carboxylate is obtained in the form of a white solid.

出典と根拠

ORDレコード: ord-a59df90ae3e14427a4e47ccad00414f7
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08697731B2

反応ノート

読み込み中…

参加物