Hydrochloric Acid → (6-Aminopyrimidin-4-yl)methanol
反応式
Cl.C(OC(=O)[NH:8][C:9]1[CH:14]=[C:13]([CH2:15][OH:16])[N:12]=[CH:11][N:10]=1)(C)(C)C>CO>[NH2:8][C:9]1[N:10]=[CH:11][N:12]=[C:13]([CH2:15][OH:16])[CH:14]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
Concentrated hydrochloric acid (0.80 mL) was added to a solution of tert-butyl-6-(hydroxymethyl)pyrimidin-4-ylcarbamate (0.50 g, 2.2 mmol) in MeOH (10 mL). The reaction was stirred at 25° C. for 1 hour and then concentrated under reduced pressure to give the desired compound (0.50 g) as a pale yellow solid, which was used in the next step without further purification. LCMS (ESI) m/z: 126.0 [M+H+].
後処理
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-4ee2171d8ce14c84bfb1b34a2b61bd25
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697708B2
反応ノート
読み込み中…