2-Iodoxybenzoic acid → HCID 62501749、化合物

HRID 2366189ノート

反応式

HRID 2366189 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1.I(C1C=CC=CC=1C(O)=O)(=O)=O>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[S:10][CH:11]=[C:12]([CH:14]=[O:15])[N:13]=1

参加物

4

反応物 2

HCID 1087942-Iodoxybenzoic acidHCID 39347891HCID 39347891、化合物

生成物 1

HCID 62501749HCID 62501749、化合物収率 93.1%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
70 °C

実験手順

To a stirred solution of (2-(2-chloro-6-fluorophenyl)thiazol-4-yl)methanol (5.8 g, 24 mmol) in EtOAc (200 mL) at room temperature was added 2-iodoxybenzoic acid (12.5 g, 44.6 mmol). The resulting mixture was heated at 70° C. for 18 hours. After cooling to room temperature, the residual solid was removed via filtration and the filtrate was concentrated under reduced pressure to give the crude desired product as a white solid (5.4 g, 93% yield) which was used in the next step without further purification.

後処理

  1. temperatureAfter cooling to room temperature
  2. customthe residual solid was removed via filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-bf8dfd389e81434c8fe3c0e4a7b4c9fa
出典データセット
uspto-grants-2014_04
特許番号
US08697708B2

反応ノート

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