Hydrochloric Acid → HCID 11965253、化合物

HRID 2366370ノート

反応式

HRID 2366370 の反応式
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[C:12](=[CH:15]/[C:16]2[S:17][C:18]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:19][CH:20]=2)/[C:13]#[N:14])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 11965251HCID 11965251、化合物

生成物 1

HCID 11965253HCID 11965253、化合物収率 94%

実験手順

0.1N Hydrochloric acid (7.0 mL) was added to Compound 4 (226 mg), and purified water (30 mL), acetonitrile (30 mL), and chloroform (3 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 235 mg, 94%).

後処理

  1. custompurified water (30 mL), acetonitrile (30 mL), and chloroform (3 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

出典と根拠

ORDレコード
ord-231344f792c6483a9607f331926078bf
出典データセット
uspto-grants-2014_04
特許番号
US08697742B2

反応ノート

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