Hydrochloric Acid → (Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile hydrochloride

HRID 2366378ノート

反応式

HRID 2366378 の反応式
[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12](/[CH:14]=[C:15](/[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=3)\[C:16]#[N:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1>>[ClH:1].[NH2:2][C:3]1[CH:4]=[C:5]([C:9]2[O:13][C:12](/[CH:14]=[C:15](/[C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=3)\[C:16]#[N:17])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 11842656(Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile

生成物 1

HCID 67226969(Z)-3-[5-(3-amino-phenyl)-furan-2-yl]-2-(3,4-dimethoxy-phenyl)-acrylonitrile hydrochloride収率 96%

実験手順

0.1N Hydrochloric acid (3.7 mL) was added to Compound 22 (117 mg), and purified water (30 mL), acetonitrile (30 mL), and chloroform (5 mL) were added to the mixture, to thereby dissolve the mixture. The solution was stirred at room temperature for 1 hour, and the solvent was evaporated to dryness. The residue was suspended in hexane-ethyl acetate, and the solvent was evaporated to dryness, followed by thoroughly drying, to thereby yield the target product (yield: 124 mg, 96%).

後処理

  1. custompurified water (30 mL), acetonitrile (30 mL), and chloroform (5 mL)
  2. additionwere added to the mixture
  3. dissolutionto thereby dissolve the mixture
  4. customthe solvent was evaporated to dryness
  5. customthe solvent was evaporated to dryness
  6. customby thoroughly drying

出典と根拠

ORDレコード
ord-1aaf467c33b14aa2887449371b344046
出典データセット
uspto-grants-2014_04
特許番号
US08697742B2

反応ノート

読み込み中…