Morpholine → (Z)-2-(3,4-dimethoxy-phenyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile

HRID 2366380

反応式

HRID 2366380 の反応式
N1CCOCC1.BrC1OC(C=O)=CC=1.[N:15]1([C:21]2[O:25][C:24]([CH:26]=O)=[CH:23][CH:22]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.[CH3:28][O:29][C:30]1[CH:31]=[C:32]([CH:36]=[CH:37][C:38]=1[O:39][CH3:40])[CH2:33][C:34]#[N:35]>>[CH3:28][O:29][C:30]1[CH:31]=[C:32](/[C:33](=[CH:26]/[C:24]2[O:25][C:21]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)=[CH:22][CH:23]=2)/[C:34]#[N:35])[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]

参加物

5

反応物 4

HCID 8083MorpholineHCID 667273,4-DimethoxybenzeneacetonitrileHCID 6003285-Bromofuran-2-carbaldehydeHCID 6023085-Morpholin-4-yl-2-furaldehyde2 回

生成物 1

HCID 11965418(Z)-2-(3,4-dimethoxy-phenyl)-3-(5-morpholin-4-yl-furan-2-yl)-acrylonitrile収率 40%

実験手順

Through the procedure as employed in Production step 1, an amine moiety derived from morpholine (523 mg) was introduced into 5-bromo-2-furaldehyde (350 mg), to thereby yield 5-morpholin-4-yl-furan-2-carbaldehyde (yield: 138 mg, 38%). The produced 5-morpholin-4-yl-furan-2-carbaldehyde (137 mg) was condensed with 3,4-dimethoxybenzyl cyanide (135 mg) through Method A (production step 2), to thereby yield the target product (yield: 102 mg, 40%).

出典と根拠

ORDレコード
ord-232e68d47d28499b903c549e398ca29b
出典データセット
uspto-grants-2014_04
特許番号
US08697742B2

関連ノート

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