Hydrochloric Acid → HCID 67226852、化合物

反応式

[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:12]=[C:13](/[C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)\[C:14]#[N:15])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 5468216(Z)-3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile

生成物 1

HCID 67226852HCID 67226852、化合物収率 99%

実験手順

0.1N Hydrochloric acid (8.3 mL) was added to Compound 44 (200 mg) for dissolution, and purified water (5 mL) was added to the solution, followed by stirring at room temperature for 20 minutes. The reaction mixture was lyophilized, to thereby yield the target product (yield: 224 mg, 99%).

後処理

custompurified water (5 mL)
additionwas added to the solution

出典と根拠

ORDレコード: ord-092d2958f5f94ff3b76d3d0f43164c33
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08697742B2

反応ノート

読み込み中…

参加物