Carbamic acid, [3-(bromoacetyl)phenyl]-, ethyl ester → HCID 178419570、化合物

HRID 236641

反応式

HRID 236641 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:6]=[C:7]([NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])[CH:8]=[CH:9][CH:10]=1)=O.[C:17]([NH:20][C:21]([NH2:23])=[S:22])(=[NH:19])[NH2:18]>C(O)C>[BrH:1].[NH:20]([C:21]1[S:22][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])[CH:8]=[CH:9][CH:10]=2)[N:23]=1)[C:17]([NH2:19])=[NH:18]

参加物

4

反応物 2

HCID 20216369Carbamic acid, [3-(bromoacetyl)phenyl]-, ethyl esterHCID 178513045HCID 178513045、化合物

生成物 1

HCID 178419570HCID 178419570、化合物収率 94.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 17.17 gm of ethyl N-[3-(2-bromoacetyl)-phenyl]-carbamate, 7.1 gm of amidinothiourea and 45 ml of ethanol was refluxed for 4 hours and then cooled to room temperature. The precipitate formed thereby was filtered off and washed with cold ethanol, yielding 22 gm of the title compound, m.p. 240°-2° C.

後処理

  1. temperaturewas refluxed for 4 hours
  2. customThe precipitate formed
  3. filtrationthereby was filtered off
  4. washwashed with cold ethanol

出典と根拠

ORDレコード
ord-6d885af43e5a42df8c8026180f6c9d4f
出典データセット
uspto-grants-1987_02
特許番号
US04645841

関連ノート

読み込み中…