Hydrochloric Acid → 1-[5-[(Z)-2-cyano-2-(3,4-dimethoxy-phenyl)-vinyl]-thiophen-2-yl]-piperidin-4-yl diethylamino-acetate hydrochloride
反応式
[ClH:1].[CH2:2]([N:4]([CH2:7][C:8]([O:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[S:18][C:19](/[CH:22]=[C:23](\[C:34]#[N:35])/[C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH3:33])[CH:25]=3)=[CH:20][CH:21]=2)[CH2:13][CH2:12]1)=[O:9])[CH2:5][CH3:6])[CH3:3]>C(O)(C)C>[ClH:1].[CH2:2]([N:4]([CH2:7][C:8]([O:10][CH:11]1[CH2:12][CH2:13][N:14]([C:17]2[S:18][C:19](/[CH:22]=[C:23](\[C:34]#[N:35])/[C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26]([O:32][CH3:33])[CH:25]=3)=[CH:20][CH:21]=2)[CH2:15][CH2:16]1)=[O:9])[CH2:5][CH3:6])[CH3:3]参加物
4
反応条件
- 温度
- 80 °C
実験手順
Isopropanol (10 mL) and 12N hydrochloric acid (59 μL) were added to Compound 103 (338 mg), and the mixture was heated for dissolution (external temperature: 80° C.). The solution was returned to room temperature, and allowed to stand overnight. The precipitated crystals were recovered through filtration, and the recovered crystals were recrystallized from isopropanol, to thereby yield the target product (yield: 254.5 mg, 70.0%).