Methylamine → HCID 10149078、化合物
反応式
[CH3:1][NH2:2].[F:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:14][O:13]2)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>ClCCl>[CH3:1][NH:2][CH2:14][CH:12]([C:6]1[CH:5]=[C:4]([F:3])[C:9]([F:10])=[C:8]([F:11])[CH:7]=1)[OH:13]参加物
4
実験手順
To a solution of methylamine (20 mL, 2.0 M in methanol, 40 mmol) was added 2-(3,4,5-trifluorophenyl)oxirane (0.17 g, 0.98 mmol) at room temperature. The reaction mixture was stirred at that temperature for 24 hours. Solvent and excessive methylamine were evaporated, leaving a solid. The solid was dissolved in dichloromethane (5 mL). To the resulting clear solution was added hexanes (15 mL), standing overnight. The solid precipitant was collected by filtration to yield the title compound (0.14 g) as a white solid.
後処理
- customSolvent and excessive methylamine were evaporated
- customleaving a solid
- waitstanding overnight
- filtrationThe solid precipitant was collected by filtration
出典と根拠
- ORDレコード
- ord-8fbffc257eda42ab9f5c8744de2362f5
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852731B2
反応ノート
読み込み中…