Hydrochloric Acid → 5-(1,1,2-Trifluoro-2-(perfluoropropoxy)ethoxy)isophthalic acid

HRID 2366507ノート

反応式

HRID 2366507 の反応式
[F:1][C:2]([F:31])([O:16][C:17]1[CH:18]=[C:19]([C:27]([O:29]C)=[O:28])[CH:20]=[C:21]([CH:26]=1)[C:22]([O:24]C)=[O:23])[CH:3]([F:15])[O:4][C:5]([F:14])([F:13])[C:6]([F:12])([F:11])[C:7]([F:10])([F:9])[F:8].[OH-].[K+].Cl>O>[F:1][C:2]([F:31])([O:16][C:17]1[CH:26]=[C:21]([C:22]([OH:24])=[O:23])[CH:20]=[C:19]([CH:18]=1)[C:27]([OH:29])=[O:28])[CH:3]([F:15])[O:4][C:5]([F:13])([F:14])[C:6]([F:11])([F:12])[C:7]([F:8])([F:10])[F:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58426160Dimethyl 5-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)isophthalate

生成物 1

HCID 866753405-(1,1,2-Trifluoro-2-(perfluoropropoxy)ethoxy)isophthalic acid収率 85.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Dimethyl 5-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)isophthalate (47.6 g, 0.10 mol) was added to a solution of water (1.00 L) and KOH (206 g, 3.5 mol). The resulting solution was heated to reflux for about 48 hours. The reaction was cooled to room temperature and then acidified to a pH of about 1 with concentrated HCl. The precipitate material was filtered and then dried under vacuum for 4 days to give 38.51 g of product.

後処理

  1. temperatureThe resulting solution was heated
  2. temperatureto reflux for about 48 hours
  3. filtrationThe precipitate material was filtered
  4. customdried under vacuum for 4 days

出典と根拠

ORDレコード
ord-7989048dce46449ea184bb1fc0150576
出典データセット
uspto-grants-2014_04
特許番号
US08697831B2

反応ノート

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