1,1,1-Trimethoxybutane → HCID 57447034、化合物

HRID 2366637ノート

反応式

HRID 2366637 の反応式
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][CH:8]=[CH:7][CH:6]=2.[C:20](OC)(OC)(OC)[CH2:21][CH2:22][CH3:23]>C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>[CH2:21]([C:20]1[N:12]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:11]2[C:10]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[N:4]=[CH:3][C:2]=2[N:1]=1)[CH2:22][CH3:23]

参加物

4

反応物 2

HCID 1235121,1,1-TrimethoxybutaneHCID 68874499HCID 68874499、化合物

生成物 1

HCID 57447034HCID 57447034、化合物収率 80.3%

試薬・触媒・溶媒 1

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)触媒

実験手順

Ethyl N-(3-aminoquinolin-4-yl)-β-alaninate (11.0 g, 42.4 mmol) was treated according to a modification of the method described in Part B of Example 8. After the addition of trimethyl orthobutyrate (7.8 mL, 49 mmol) and pyridinium p-toluenesulfonate (0.200 g, 0.796 mmol), the reaction was heated at reflux for one hour and subjected to the work-up procedure to provide 10.6 g of ethyl 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate, which was used without purification.

後処理

  1. temperaturethe reaction was heated
  2. temperatureat reflux for one hour

出典と根拠

ORDレコード
ord-7f1215e826d14873aa586cad1a8ed7b5
出典データセット
uspto-grants-2014_04
特許番号
US08697873B2

反応ノート

読み込み中…