HCID 67415648、化合物 → Di-tert-butyl (5-amino-2-fluorophenyl)imidodicarbonate

HRID 2366770ノート

反応式

HRID 2366770 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[N:11]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>CO.[C].[Pd]>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([N:11]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C:12]([O:14][C:15]([CH3:17])([CH3:18])[CH3:16])=[O:13])[CH:4]=1

参加物

4

反応物 1

HCID 67415648HCID 67415648、化合物

生成物 1

HCID 67414473Di-tert-butyl (5-amino-2-fluorophenyl)imidodicarbonate収率 64%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To a solution of di-tert-butyl (2-fluoro-5-nitrophenyl)imidodicarbonate (256 mg, 0.718 mmol) in methanol (10 mL) was added 10% palladium-carbon (50 mg), and the mixture was stirred at room temperature overnight under a hydrogen atmosphere. The insoluble material was filtered off through celite, and the filtrate was concentrated under reduced pressure to give the title compound (150 mg, 64%).

後処理

  1. filtrationThe insoluble material was filtered off through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-96d6d76da5574f4980e35b4e60b98775
出典データセット
uspto-grants-2014_04
特許番号
US08697874B2

反応ノート

読み込み中…