Lasmiditan → (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone
反応式
FC1C=C(F)C=C(F)C=1C([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[O:14])[N:8]=1)=O.Br.BrC1N=C(C(C2CCN(C)CC2)=O)C=CC=1>[Cu-]=O>[NH2:6][C:7]1[N:8]=[C:9]([C:13]([CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[O:14])[CH:10]=[CH:11][CH:12]=1参加物
4
実験手順
The present invention relates to a process for preparing 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide or a salt thereof, comprising the step of: reacting (6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide with >0.02 wt % copper(I)oxide at less than 80° C. to yield (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone.
後処理
- customat less than 80° C.
出典と根拠
- ORDレコード
- ord-2b87311581df43f1b899300af88c00da
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697876B2
反応ノート
読み込み中…