6-Chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamine → HCID 58504374、化合物

HRID 2367207ノート

反応式

HRID 2367207 の反応式
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[C:6]([F:10])[C:7]=1[CH:8]=[O:9].Cl[C:15]1[N:20]=[C:19]([NH2:21])[N:18]=[C:17]([N:22]([CH3:24])[CH3:23])[CH:16]=1>CCOC(C)=O>[NH2:21][C:19]1[N:20]=[C:15]([C:4]2[CH:3]=[C:2]([F:1])[C:7]([CH:8]=[O:9])=[C:6]([F:10])[CH:5]=2)[CH:16]=[C:17]([N:22]([CH3:24])[CH3:23])[N:18]=1

参加物

4

反応物 2

HCID 2517356-Chloro-N~4~,N~4~-dimethylpyrimidine-2,4-diamineHCID 162177083,5-Difluoro-4-formylphenylboronic acid

生成物 1

HCID 58504374HCID 58504374、化合物収率 80%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The title compound was prepared following the General Procedure A using: (3,5-difluoro-4-formylphenyl)boronic acid (2.37 g, 12.8 mmol) and 6-chloro-N4,N4-dimethyl-2,4-pyrimidinediamine (2.2 g, 12.8 mmol). The solid was dissolved in EtOAc and precipitated with hexanes. The resulting solid was collected via vacuum filtration to afford the title compound (2.82 g, 80%) as a yellow solid. LC-MS (ES) m/z=279 [M+H]+.

後処理

  1. customThe title compound was prepared
  2. customprecipitated with hexanes
  3. filtrationThe resulting solid was collected via vacuum filtration

出典と根拠

ORDレコード
ord-70a2ee2b89f1414c84b29acd83ab527d
出典データセット
uspto-grants-2014_04
特許番号
US08697685B2

反応ノート

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