2-Bromopropane → 4-(Methoxymethyl)-N-phenyl-1-(propan-2-yl)piperidin-4-amine

HRID 236777ノート

反応式

HRID 236777 の反応式
Br[CH:2]([CH3:4])[CH3:3].[CH3:5][O:6][CH2:7][C:8]1([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.C(N(CC)C(=O)C)C>CN(C)C(=O)C>[CH3:5][O:6][CH2:7][C:8]1([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:13][CH2:12][N:11]([CH:2]([CH3:4])[CH3:3])[CH2:10][CH2:9]1

参加物

5

反応物 3

HCID 63582-BromopropaneHCID 12703N,N-DiethylacetamideHCID 183199324-(Methoxymethyl)-N-phenylpiperidin-4-amine

生成物 1

HCID 233390404-(Methoxymethyl)-N-phenyl-1-(propan-2-yl)piperidin-4-amine収率 42.6%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

A mixture of 10 parts of 2-bromopropane, 9 parts of 4-(methoxymethyl)-N-phenyl-4-piperidinamine, 4.9 parts of N,N-diethylethanamide and 72 parts of N,N-dimethylacetamide is stirred and refluxed for 10.25 hours. After cooling, the formed N,N-diethylethanamine hydrobromide is filtered off and the filtrate is diluted with water. The product is extracted with methylbenzene. The extract is washed thoroughly with water, dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (90:10) as eluent. The pure fractions are collected and the eluent is evaporated, yielding 5.7 parts (42.6%) of 4-(methoxymethyl)-1-(1-methylethyl)-N-phenyl-4-piperidinamine as an oily residue.

後処理

  1. temperaturerefluxed for 10.25 hours
  2. temperatureAfter cooling
  3. filtrationthe formed N,N-diethylethanamine hydrobromide is filtered off
  4. additionthe filtrate is diluted with water
  5. extractionThe product is extracted with methylbenzene
  6. washThe extract is washed thoroughly with water
  7. customdried
  8. filtrationfiltered
  9. customevaporated
  10. customThe residue is purified by column-chromatography over silica gel using
  11. additiona mixture of trichloromethane and methanol (90:10) as eluent
  12. customThe pure fractions are collected
  13. customthe eluent is evaporated

出典と根拠

ORDレコード
ord-3cb8a07bc3fd4993b51c0996b0c2daab
出典データセット
uspto-grants-1979_06
特許番号
US04157393

反応ノート

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