Ammonia → 2-Phenyl-3-phenylamino-benzo(b)thiophene

HRID 236796

反応式

HRID 236796 の反応式
[C:1]1([S:7][CH:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9](O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:18]>C1C=CC=CC=1>[C:12]1([C:8]2[S:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=3[C:9]=2[NH:18][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 2396052-Phenyl-2-(phenylsulfanyl)acetic acid

生成物 1

HCID 166403612-Phenyl-3-phenylamino-benzo(b)thiophene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

3.0 g of anilide of phenylthio-phenyl acetic acid (colourless needles in a mixture of benzene and petroleum ether mp 142°-143°) in 130 g of polyphosphoric acid are heated to 100° for 19 hours. The cooled reaction mixture is poured onto water, made alkaline by concentrated ammonia and extracted with methylene chloride. By drying over sodium sulphate and evaporating the extracts of methylene chloride, 1.7 g (60.0% of theory) of yellow oil are obtained which are recrystallized in ethanol: 1.5 g (45% of theory) of yellow crystals, mp 150°-151° (ethanol).

後処理

  1. temperatureare heated to 100° for 19 hours
  2. customThe cooled reaction mixture
  3. additionis poured onto water
  4. extractionextracted with methylene chloride
  5. dry with materialBy drying over sodium sulphate
  6. customevaporating the extracts of methylene chloride, 1.7 g (60.0% of theory) of yellow oil
  7. customare obtained which
  8. customare recrystallized in ethanol

出典と根拠

ORDレコード
ord-72aa0048b1f947589c78b839a1434659
出典データセット
uspto-grants-1979_06
特許番号
US04157399

関連ノート

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