関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trifluoroiodomethane | HCID 16843 | — |
| 反応物 | Ethyl 3-bromo-4-cyclohexylphenylglyoxylate | HCID 20515211 | — |
| 触媒 | Copper | HCID 23978 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl 3-trifluoromethyl-4-cyclohexylphenylglyoxylate | HCID 20515217 | — |
反応手順
To a solution of 0.01 moles of ethyl 3-bromo-4-cyclohexylphenylglyoxylate in 50 ml. of dimethylformamide is added 0.15 moles of trifluoromethyl iodide and 0.02 g. of copper powder. The reaction is shaken in a sealed tube for 5 hours at 140° C., cooled, and then filtered and evaporated in vacuo. 200 ml. of water is added to the residue and extracted with ether. The ether extract is dried, evaporated to dryness and distilled to obtain ethyl 3-trifluoromethyl-4-cyclohexylphenylglyoxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04157449 |
|---|
| 出典データセット | uspto-grants-1979_06 |
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| ORD ID | ord-19b836a8a39747908dae12e239649e0f |
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| 出典メモ | uspto-grants-1979_06 |
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