4-Methylmorpholine → HCID 57476907、化合物

HRID 2368440ノート

反応式

HRID 2368440 の反応式
[NH2:1][C:2]([CH3:8])([CH3:7])[C:3]([O:5][CH3:6])=[O:4].CN1CCOCC1.Cl[C:17]([O:19][C:20]1[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=1)=[O:18]>C(Cl)Cl>[CH3:7][C:2]([NH:1][C:17]([O:19][C:20]1[CH:21]=[CH:22][C:23]([N+:26]([O-:28])=[O:27])=[CH:24][CH:25]=1)=[O:18])([CH3:8])[C:3]([O:5][CH3:6])=[O:4]

参加物

5

反応物 3

HCID 79724-MethylmorpholineHCID 821294-Nitrophenyl chloroformateHCID 4186341Methyl 2-amino-2-methylpropanoate

生成物 1

HCID 57476907HCID 57476907、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of Methyl 2-amino-2-methylpropanoate (5 g, 32 mmol) and N-Methyl morpholine (11 mL, 98 mmol) in DCM (30 mL) was added in one portion 4-nitrophenyl chloroformate (9.8 g, 49 mmol). Diluted reaction with DCM (50 mL) washed with 1N HCl (2×20 mL) and sat. NaHCO3 (2×20 mL), dried organic fraction over magnesium sulfate, filtered and evaporated volatiles in vacuo.

後処理

  1. additionDiluted
  2. washwashed with 1N HCl (2×20 mL) and sat. NaHCO3 (2×20 mL), dried organic fraction over magnesium sulfate
  3. filtrationfiltered
  4. customevaporated volatiles in vacuo

出典と根拠

ORDレコード
ord-c2902a82dae542ceafd4da0b2352c137
出典データセット
uspto-grants-2014_04
特許番号
US08703761B2

反応ノート

読み込み中…