Water → 6-Amino-5-nitroso-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

HRID 2368545ノート

反応式

HRID 2368545 の反応式
[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6](=[S:13])[NH:5][C:4](=[O:14])[CH:3]=1.[N:15]([O-])=[O:16].[Na+].O>C(O)(=O)C>[NH2:1][C:2]1[N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6](=[S:13])[NH:5][C:4](=[O:14])[C:3]=1[N:15]=[O:16]

参加物

5

反応物 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 576001846-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

生成物 1

HCID 576001906-Amino-5-nitroso-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
75 °C

実験手順

6-Amino-1-pentyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (8.0 g, 0.038 mol) was mixed with sodium nitrite (3.1 g, 0.045 mol) in acetic acid (120 mL). The mixture was stirred at 75° C. for 1 h. The color of the reaction mixture became pink and then purple. The solution was allowed to cool down to room temperature, and water (40 mL) was added. The solid was collected by suction filtration and washed with water (50 mL) to produce the desired product, which was used directly for next step without further purification. LCMS calculated for C9H15N4O2S: (M+H) 243.1. Found 243.1.

後処理

  1. temperatureto cool down to room temperature
  2. filtrationThe solid was collected by suction filtration
  3. washwashed with water (50 mL)

出典と根拠

ORDレコード
ord-3f70140d979b442c9f1daaa3e5cc3819
出典データセット
uspto-grants-2014_04
特許番号
US08703783B2

反応ノート

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