Hydrazine → HCID 178446160、化合物

HRID 2368582ノート

反応式

HRID 2368582 の反応式
[CH:1]1([C:5]2[NH:13][C:12]3[C:11](=[O:14])[NH:10][C:9](=S)[N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]=3[N:6]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:21][NH2:22]>O>[CH:1]1([C:5]2[NH:13][C:12]3[C:11](=[O:14])[NH:10]/[C:9](=[N:21]\[NH2:22])/[N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]=3[N:6]=2)[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 9321HydrazineHCID 576002418-cyclobutyl-3-pentyl-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

生成物 1

HCID 178446160HCID 178446160、化合物収率 38.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

The mixture of 8-cyclobutyl-3-pentyl-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one (0.6 g, 2.0 mmol) in 20 M of hydrazine in water (20 mL) was stirred at 100° C. overnight. After cooling to room temperature, the solid formed was filtered and dried Cooled down, the solid was isolated to give yield the desired product (230 mg, 38.6%). LCMS calculated for C14H23N6O (M+H): 291.2. Found: 291.2.

後処理

  1. temperatureAfter cooling to room temperature
  2. customthe solid formed
  3. filtrationwas filtered
  4. customdried
  5. temperatureCooled down
  6. customthe solid was isolated
  7. customto give

出典と根拠

ORDレコード
ord-3a6646649f6b495babc0f16ac5e4621c
出典データセット
uspto-grants-2014_04
特許番号
US08703783B2

反応ノート

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