Ammonia hydroxide → 2-amino-3-pentyl-3,7-dihydro-6H-purin-6-one

HRID 2368612ノート

反応式

HRID 2368612 の反応式
CS[C:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:17])[N:4]=1.[OH-].[NH3:19]>>[NH2:19][C:3]1[N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:17])[N:4]=1

参加物

3

反応物 2

HCID 21862953Ammonia hydroxideHCID 576002282-(methylthio)-3-pentyl-3,7-dihydro-6H-purin-6-one

生成物 1

HCID 576003172-amino-3-pentyl-3,7-dihydro-6H-purin-6-one収率 68%

反応条件

温度
100 °C

実験手順

2-(Methylthio)-3-pentyl-3,7-dihydro-6H-purin-6-one (5.0 g, 0.020 mol) was mixed with 100 ml of 28% ammonia hydroxide in a seal tube. The mixture was stirred at 100° C. for 4 days. After cooling to room temperature, the solid was filtered and dried to yield the desired product (3.0 g, 68%). LCMS calculated for C10H16N5O (M+H): 222.1. Found: 222.1.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was filtered
  3. customdried

出典と根拠

ORDレコード
ord-92390f00e28345339c964165e72a767b
出典データセット
uspto-grants-2014_04
特許番号
US08703783B2

反応ノート

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