Potassium tert-butoxide → 3-((4-amino-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one

HRID 2368816ノート

反応式

HRID 2368816 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[C:17]3[C:12](=[N:13][CH:14]=[N:15][C:16]=3[NH2:18])[NH:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1.CC(C)([O-])C.[K+].Br[CH2:26][C:27]1[N:28]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[CH3:45])[C:29](=[O:38])[C:30]2[C:35]([CH:36]=1)=[CH:34][CH:33]=[CH:32][C:31]=2[CH3:37]>CN(C=O)C>[NH2:18][C:16]1[N:15]=[CH:14][N:13]=[C:12]2[N:11]([CH2:26][C:27]3[N:28]([C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=4[CH3:45])[C:29](=[O:38])[C:30]4[C:35]([CH:36]=3)=[CH:34][CH:33]=[CH:32][C:31]=4[CH3:37])[N:10]=[C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([OH:2])[CH:4]=3)[C:17]=12.[NH2:18][C:16]1[N:15]=[CH:14][N:13]=[C:12]2[N:11]([CH2:26][C:27]3[N:28]([C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=4[CH3:45])[C:29](=[O:38])[C:30]4[C:35]([CH:36]=3)=[CH:34][CH:33]=[CH:32][C:31]=4[CH3:37])[N:10]=[C:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:17]=12

参加物

6

反応物 3

HCID 23665647Potassium tert-butoxideHCID 580086503-(Bromomethyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-oneHCID 1784899393-(3-Methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

生成物 2

HCID 580086943-((4-amino-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one収率 139.3%HCID 580087113-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3-(3-Methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (1701) (964 mg, 4 mmol) and potassium tert-butoxide (0.44 g, 4 mmol) were dissolved in anhydrous DMF (150 mL) and stirred at RT for 30 min. 3-(Bromomethyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one (1607) (1.37 g, 4.0 mmol) was added. The resulting mixture was stirred at RT for 30 min, poured into ice water (30 mL) and then extracted with ethyl acetate (3×50 mL). The combined organic layer was washed with brine (25 mL), dried over Na2SO4 and filtered. The filtrate was concentrated in vacuo and the residue was purified by flash column chromatography on silica gel (2-20% MeOH/DCM) to afford the desired product, 3-((4-amino-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one (1702) (1.4 g, 70% yield) as a white solid.

後処理

  1. stirringThe resulting mixture was stirred at RT for 30 min
  2. extractionextracted with ethyl acetate (3×50 mL)
  3. washThe combined organic layer was washed with brine (25 mL)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated in vacuo
  7. customthe residue was purified by flash column chromatography on silica gel (2-20% MeOH/DCM)

出典と根拠

ORDレコード
ord-101a585eec6f4cb3ac9d33872041d5d2
出典データセット
uspto-grants-2014_04
特許番号
US08703777B2

反応ノート

読み込み中…