Triethylamine → HCID 21315337、化合物

HRID 236904ノート

反応式

HRID 236904 の反応式
C[C:2]1[O:6][C:5]([NH:7][CH2:8][CH2:9][CH3:10])=[N:4][N:3]=1.[CH:11]1([C:15](Cl)=[O:16])[CH2:14][CH2:13][CH2:12]1.[CH2:18](N(CC)CC)C>C1C=CC=CC=1>[CH3:18][N:4]1[N:3]=[CH:2][O:6][CH:5]1[N:7]([CH2:8][CH2:9][CH3:10])[C:15]([CH:11]1[CH2:14][CH2:13][CH2:12]1)=[O:16]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 541521435-Methyl-N-propyl-1,3,4-oxadiazol-2-amine2 回

生成物 1

HCID 21315337HCID 21315337、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

5-Methyl-2-n-propylamino 1,3,4-oxadiazole (6 g, 0.04 mol) prepared as in (b) above, was refluxed with cyclobutanecarboxylic acid chloride (5.5 g, 0.05 mol) in benzene (25 ml) in the presence of triethylamine (4.72 g, 0.05 mol) for 2 hours. The mixture was filtered and the filtrate washed with dilute HCl, saturated solution NaHCO3 and water; dried over magnesium sulphate, filtered, solvent evaporated off to yield a reddish brown liquid which was distilled twice in a vigreux flask to yield the title compound as a slightly pink liquid (b.p. 110°-111° C./0.27 mm Hg).

後処理

  1. filtrationThe mixture was filtered
  2. washthe filtrate washed with dilute HCl, saturated solution NaHCO3 and water
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customsolvent evaporated off
  6. customto yield a reddish brown liquid which
  7. distillationwas distilled twice in a vigreux flask

出典と根拠

ORDレコード
ord-92f8f67134e14fb5b678adb4f10b7c87
出典データセット
uspto-grants-1979_06
特許番号
US04158659

反応ノート

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