Hydrazine → HCID 68656452、化合物

反応式

[F:1][C:2]([F:24])([F:23])[C:3](=O)[CH2:4][C:5]([C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:13]=2)=[CH:10][CH:11]=1)=O.[NH2:25][NH2:26]>>[CH3:21][S:18]([C:14]1[CH:13]=[C:12]([C:9]2[S:8][C:7]([C:5]3[CH:4]=[C:3]([C:2]([F:24])([F:23])[F:1])[NH:26][N:25]=3)=[CH:11][CH:10]=2)[CH:17]=[CH:16][CH:15]=1)(=[O:20])=[O:19].[NH:25]1[CH:4]=[CH:3][CH:2]=[N:26]1

参加物

反応物 2

HCID 9321Hydrazine

HCID 59632690HCID 59632690、化合物

生成物 1

HCID 68656452HCID 68656452、化合物

実験手順

Another method used for preparing examples of the invention is shown as Example 60. 4,4,4-Trifluoro-1-[5-(3-methanesulfonyl-phenyl)-thiophen-2-yl]-butane-1,3-dione was condensed directly with hydrazine to form pyrazole 3-[5-(3-Methanesulfonyl-phenyl)-thiophen-2-yl]-5-trifluoromethyl-1H-pyrazole. Alkylation of a pyrazole such as 3-[5-(3-Methanesulfonyl-phenyl)-thiophen-2-yl]-5-trifluoromethyl-1H-pyrazole could result in a mixture of positional isomers which could be separated by one skilled in the art

出典と根拠

ORDレコード: ord-86d74888259845b29b4bc9d264f5eedd
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08703805B2

反応ノート

読み込み中…

参加物