Bromine → N-[4-(2-Bromoacetyl)Phenyl]Acetamide

HRID 23692

反応式

HRID 23692 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([CH3:13])=[O:12])=[CH:6][CH:5]=1)=[O:3].[Br:14]Br>O1CCOCC1.C(OCC)C>[Br:14][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:12])[CH3:13])=[CH:6][CH:5]=1)=[O:3]

参加物

4

反応物 2

HCID 24408BromineHCID 75937N-(p-acetylphenyl)acetamide

生成物 1

HCID 12364739N-[4-(2-Bromoacetyl)Phenyl]Acetamide収率 62.5%

試薬・触媒・溶媒 1

HCID 23504442p-Dioxane ethyl ether溶媒

実験手順

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

後処理

  1. filtrationThe solid was collected by filtration
  2. washwashed with diethyl ether
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-43e73a7d6a6541cb8fbdd66d015a07f5
出典データセット
uspto-grants-2005_02
特許番号
US06852731B2

関連ノート

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