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Methylamine → 2-((Methylamino)methyl)fluorene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | N-methyl fluorene-2-carboxamide | HCID 10704314 | — |
| 反応物 | 9H-Fluorene-2-carbonyl chloride | HCID 17815629 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-((Methylamino)methyl)fluorene | HCID 12689751 | — |
反応手順
A solution of fluorene-2-carbonyl chloride (prepared from fluorene-2-carboxylic acid and oxalyl chloride) in THF is added to aqueous methylamine (2 molar equivalents) to prepare N-methyl fluorene-2-carboxamide. Reduction of the amide using LiAlH4 in ether provides 2-((methylamino)methyl)fluorene. The amine is protected by reaction with di-tert-butyl dicarbonate to provide 2-((N-tBOC—N-methylamino)methyl)fluorene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08703907B2 |
| 出典データセット | uspto-grants-2014_04 |
| ORD ID | ord-c73659778c2e4efd86e08a62815c9238 |
| 出典メモ | uspto-grants-2014_04 |