Tetrafluoroethylene → 4-(3,4-Dichlorophenyl)-2-(1,1,2,2-tetrafluoroethylthio)-5-(2-thienyl)-1H-imidazole

HRID 237004

反応式

HRID 237004 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([SH:19])[NH:12][C:13]=2[C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].[F:20][C:21]([F:25])=[C:22]([F:24])[F:23]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([S:19][C:22]([F:24])([F:23])[CH:21]([F:25])[F:20])[NH:12][C:13]=2[C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

3

反応物 2

HCID 8301TetrafluoroethyleneHCID 178527840HCID 178527840、化合物

生成物 1

HCID 213149924-(3,4-Dichlorophenyl)-2-(1,1,2,2-tetrafluoroethylthio)-5-(2-thienyl)-1H-imidazole

実験手順

4-(3,4-Dichlorophenyl)-5-(2-thienyl)-1H-2-imidazolethiol (30.0 g; 92 mmoles) was reacted with 15.0 g of tetrafluoroethylene as described in Example 4 E to give, after chromatography on Silicar CC No. 7 with chloroform, 19.1 g of 4-(3,4-dichlorophenyl)-2-(1,1,2,2-tetrafluoroethylthio)-5-(2-thienyl)-1H-imidazole, m.p. 178°-180° (recrystallized from toluene).

後処理

  1. customto give
  2. custom7 with chloroform, 19.1 g of 4-(3,4-dichlorophenyl)-2-(1,1,2,2-tetrafluoroethylthio)-5-(2-thienyl)-1H-imidazole, m.p. 178°-180° (recrystallized from toluene)

出典と根拠

ORDレコード
ord-f38521aec30f461d93b8edea20d116e7
出典データセット
uspto-grants-1979_06
特許番号
US04159338

関連ノート

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