Hydrochloric Acid → HCID 67449589、化合物
反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:26][CH2:27][NH:28][C:29](=[O:32])[O:30][CH3:31])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:25])[N:12]=2>CCOCC>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]([CH2:26][CH2:27][NH:28][C:29](=[O:32])[O:30][CH3:31])[C:11]2[C:16]([N:17]=1)=[C:15]([N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[N:14]=[C:13]([CH3:25])[N:12]=2参加物
4
実験手順
Add HCl (2.0 M solution in ether) (0.024 g, 0.0006 mol) to a solution of methyl N-[2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethyl]carbamate (0.3 g, 0.0006 mol) in ether (6 mL) at 0° C. and stir for 2 h at room temperature. Filter the precipitate, wash with ether, and dry under vacuum to afford the title compound (0.28 g) as a white solid. ES/MS m/z 444 (M+1).