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Potassium Hydroxide → 1-(3-Chlorophenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 1-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine | HCID 1019725 | — |
| 触媒 | titanium(III) trichloride | HCID 10313229 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
反応手順
1-[(p-Nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine is reduced with aqueous titanium trichloride in ether solution by dropwise addition of aqueous TiCl3 until the purple color is no longer discharged. The reaction progress is followed by thin layer chromatography. Work-up with concentrated ammonium hydroxide and subsequently aqueous potassium hydroxide followed by isolation, drying, and concentration of the organic layer gives 1-[p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04159331 |
| 出典データセット | uspto-grants-1979_06 |
| ORD ID | ord-abb38bd69cbe41e4b74d1fd6d4d564b2 |
| 出典メモ | uspto-grants-1979_06 |