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HRID 2370531作成日：2026年10月27日
Diisopropylethylamine → (R)-2-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)-4-methylpentan-1-ol
https://huagongshe.com/reaction/2370531
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | D(-)-Leucinol | HCID 2724002 | — |
| 反応物 | 6-(2-Chloropyridin-4-yloxy)-2-(methylsulfinyl)benzo[d]thiazole | HCID 57725430 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | (R)-2-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)-4-methylpentan-1-ol | HCID 57725426 | 38.8% |
反応手順
To the solution of 6-(2-chloropyridin-4-yloxy)-2-(methylsulfinyl)benzo[d]thiazole (26 mg, 80 μmol) in 400 μL of NMP was added (R)-2-amino-4-methylpentan-1-ol (33 μL, 250 μmol) and DIPEA (17 μL, 100 μmol). The reaction solution was stirred at 100° C. for 18 hours. The crude reaction solution was purified on prep HPLC and evaporated in vaccuo to give (R)-2-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)-4-methylpentan-1-ol (12 mg, 31 μmol) as powder. ES/MS m/z 378.1 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08710048B2 |
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| 出典データセット | uspto-grants-2014_04 |
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| ORD ID | ord-75b7c0ae9c69476da4412313c52ac0a9 |
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| 出典メモ | uspto-grants-2014_04 |
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