Choline, hydroxide → HCID 86680788、化合物
反応式
[OH:1][NH:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([N:11]([CH2:13][C:14]2[S:22][C:21]3[C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[N:19][C:18]([C:29]4[CH:30]=[N:31][C:32]([O:35][CH3:36])=[CH:33][CH:34]=4)=[N:17][C:16]=3[CH:15]=2)[CH3:12])=[N:9][CH:10]=1)=[O:4].[OH-].[OH:38][CH2:39][CH2:40][N+:41]([CH3:44])([CH3:43])[CH3:42]>C(Cl)Cl.CO>[OH:38][CH2:39][CH2:40][N+:41]([CH3:44])([CH3:43])[CH3:42].[OH:1][NH:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([N:11]([CH2:13][C:14]2[S:22][C:21]3[C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[N:19][C:18]([C:29]4[CH:30]=[N:31][C:32]([O:35][CH3:36])=[CH:33][CH:34]=4)=[N:17][C:16]=3[CH:15]=2)[CH3:12])=[N:7][CH:6]=1)=[O:4]参加物
4
実験手順
To a solution of Compound 1 (200 mg, 0.39 mmol) in DCM/MeOH (60 mL/12 mL) was added choline hydroxide (106 mg, 0.39 mmol, 45% in MeOH). The mixture was stirred at room temperature for 2 h and was then concentrated to remove ˜30 mL of the solvent. Ethyl acetate (60 mL) was added and the mixture was stirred at room temperature for 2 h. After a small amount of precipitation occurred, the mixture was concentrated to remove ˜40 mL of the solvent and additional ethyl acetate (60 mL) was added. The mixture was stirred at room temperature for 2 h and filtered to afford Compound 5 as a white solid (180 mg, 76%).