Hydrochloric Acid → 3-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

HRID 2370911ノート

反応式

HRID 2370911 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:10]([O:12]CC)=[O:11])=[CH:4][CH:3]=1.[ClH:26]>O>[ClH:26].[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 11544682Ethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

生成物 1

HCID 694540453-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 13.7 mg (0.03 mmol) of the compound from example 1h in 0.5 ml of water and 0.5 ml of 37% strength hydrochloric acid was treated in a microwave at 180° C. for 5 min. It was then evaporated to dryness under reduced pressure, the residue was taken up in a little water, and the solution was freeze-dried. This resulted in 8.0 mg of the title compound as bishydrochloride in the form of an amorphous solid.

後処理

  1. customIt was then evaporated to dryness under reduced pressure
  2. customthe solution was freeze-dried

出典と根拠

ORDレコード
ord-7c4754a6ce92406190d7e56221dfbfd3
出典データセット
uspto-grants-2014_04
特許番号
US08710232B2

反応ノート

読み込み中…