Hydrochloric Acid → Isopropyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

HRID 2370913ノート

反応式

HRID 2370913 の反応式
Cl.Cl.[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1.[CH:26](O)([CH3:28])[CH3:27]>>[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([O:14][CH:26]([CH3:28])[CH3:27])=[O:13])=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 694540453-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

生成物 1

HCID 69250787Isopropyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

実験手順

2 ml of an HCl-saturated ether solution were added to a solution of 38.0 mg (0.12 mmol) of the compound from example 1i in 5 ml of isopropanol and stirred at RT for 4 h. The solution was then concentrated to dryness, and the resulting residue was dried under high vacuum. 25 mg of the title compound resulted as bishydrochloride in the form of an amorphous solid.

後処理

  1. concentrationThe solution was then concentrated to dryness
  2. customthe resulting residue was dried under high vacuum

出典と根拠

ORDレコード
ord-edcee3a85f99416b94a67229783cb20f
出典データセット
uspto-grants-2014_04
特許番号
US08710232B2

反応ノート

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