Hydrochloric Acid → Cyclopropylmethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

HRID 2370914ノート

反応式

HRID 2370914 の反応式
Cl.Cl.[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1.[CH:26]1([CH2:29]O)[CH2:28][CH2:27]1>>[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([O:14][CH2:29][CH:26]2[CH2:28][CH2:27]2)=[O:13])=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 75644CyclopropanemethanolHCID 694540453-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

生成物 1

HCID 11516183Cyclopropylmethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

実験手順

1 ml of an HCl-saturated ether solution was added to a solution of 50.0 mg (0.16 mmol) of the compound from example 1i in 2 ml of cyclopropylcarbinol and stirred at room temperature for 12 h. The solution was then concentrated to dryness, and the resulting residue was dried under high vacuum. Purification by chromatography on silica gel with CH2Cl2/methanol as mobile phase afforded 29 mg of the title compound in the form of an amorphous solid.

後処理

  1. concentrationThe solution was then concentrated to dryness
  2. customthe resulting residue was dried under high vacuum
  3. customPurification by chromatography on silica gel with CH2Cl2/methanol as mobile phase

出典と根拠

ORDレコード
ord-30f14c5a0401438faba89436db54bfef
出典データセット
uspto-grants-2014_04
特許番号
US08710232B2

反応ノート

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