Hydrochloric Acid → 3-(6-Aminopyridin-3-yl)-2-[1-(2-oxo-1-phenylpyrrolidin-3-yl)-1H-imidazol-4-yl]propionic acid bishydrochloride

HRID 2370922ノート

反応式

HRID 2370922 の反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:24][CH2:23][N:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[C:21]3=[O:31])[CH:19]=2)[C:10]([O:12]CC)=[O:11])=[CH:4][CH:3]=1.[ClH:32]>O.C(O)C>[ClH:32].[ClH:32].[NH2:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:24][CH2:23][N:22]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[C:21]3=[O:31])[CH:19]=2)[C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 69330945Ethyl 3-(6-aminopyridin-3-yl)-2-[1-(2-oxo-1-phenylpyrrolidin-3-yl)-1H-imidazol-4-yl]-propionate

生成物 1

HCID 693314653-(6-Aminopyridin-3-yl)-2-[1-(2-oxo-1-phenylpyrrolidin-3-yl)-1H-imidazol-4-yl]propionic acid bishydrochloride

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 23.1 mg (0.06 mmol) of the compound from example 9a in 0.5 ml of water and 0.5 ml of 37% strength hydrochloric acid was treated in a microwave at 180° C. for 3 min. The reaction solution was taken up in ethanol and concentrated under reduced pressure several times. Freeze-drying of the residue taken up in water afforded 19.0 mg of the desired compound in the form of an amorphous solid.

後処理

  1. concentrationconcentrated under reduced pressure several times
  2. customFreeze-drying of the residue

出典と根拠

ORDレコード
ord-a79669d830bc438aa56faa116c13af2c
出典データセット
uspto-grants-2014_04
特許番号
US08710232B2

反応ノート

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