Ethyl isocyanate → HCID 67109704、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]=2[C:18]2[C:19]([CH3:24])=[N:20][O:21][C:22]=2[CH3:23])=[CH:5][CH:4]=1.[N:25]([CH2:28][CH3:29])=[C:26]=[O:27]>CN(C=O)C>[CH3:24][C:19]1[C:18]([C:10]2[N:11]([C:26]([NH:25][CH2:28][CH3:29])=[O:27])[C:12]3[C:17]([C:9]=2[C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:22]([CH3:23])[O:21][N:20]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
4-(3-(4-methoxyphenyl)-1H-indol-2-yl)-3,5-dimethylisoxazole (15 mg, 0.06 mmol) and isocyanatoethane (40 μl) were mixed 1 ml dry DMF under nitrogen. The mixture was heated at 70° C. for 3 h. 100 μl isocyanatoethane were added and the heating at 70° C. continued over night. The crude reaction mixture was purified by prep HPLC. 8.0 mg 2-(3,5-dimethylisoxazol-4-yl)-N-ethyl-3-(4-methoxyphenyl)-1H-indole-1-carboxamide was obtained.