Hydrochloric Acid → 1-[(1-Benzylpiperidin-3-yl)methyl]piperazin-2-one dihydrochloride

HRID 2371137ノート

反応式

HRID 2371137 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][C:16]2=[O:28])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>ClCCl.O1CCOCC1>[ClH:29].[ClH:29].[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][N:15]2[CH2:20][CH2:19][NH:18][CH2:17][C:16]2=[O:28])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 57656824Tert-butyl 4-[(1-benzylpiperidin-3-yl)methyl]-3-oxopiperazine-1-carboxylate

生成物 1

HCID 672206771-[(1-Benzylpiperidin-3-yl)methyl]piperazin-2-one dihydrochloride収率 100%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of tert-butyl 4-[(1-benzylpiperidin-3-yl)methyl]-3-oxopiperazine-1-carboxylate (95 mg) in dichloromethane (1 mL) was added 4M hydrochloric acid in dioxane (1 mL). The mixture was stirred at room temperature for 15 minutes and then evaporated to give the title compound as a sticky white solid (89 mg, 100%).

後処理

  1. customevaporated

出典と根拠

ORDレコード
ord-1797e5c91a6048c6a2b3956e8815c716
出典データセット
uspto-grants-2014_04
特許番号
US08710224B2

反応ノート

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