Water → HCID 23535509、化合物
反応式
C(OC([N:11]1[CH2:15][C@H:14]([OH:16])[CH2:13][C@H:12]1[C:17]([N:19]([CH3:21])[CH3:20])=[O:18])=O)C1C=CC=CC=1.O.[H][H]>C(O)C.[C].[Pd]>[CH3:20][N:19]([CH3:21])[C:17]([C@@H:12]1[CH2:13][C@@H:14]([OH:16])[CH2:15][NH:11]1)=[O:18]参加物
6
実験手順
To a solution of (2S,4R)-1-benzyloxycarbonyl-2-dimethylaminocarbonyl-4-hydroxypyrrolidine (5.97 g) in ethanol (60 ml), 10% palladium-carbon (containing water 50 (1.20 g) was added, and the mixture was hydrogenated at room temperature for 3 hours under an atmospheric pressure of hydrogen. After removal of the catalyst by filtration, the filtrate was evaporated to remove the solvent to give (2S,4R)-2-dimethylaminocarbonyl-4-hydroxypyrrolidine.
後処理
- additionwas added
- customAfter removal of the catalyst
- filtrationby filtration
- customthe filtrate was evaporated
- customto remove the solvent
出典と根拠
- ORDレコード
- ord-6b19aafa4c794a708e73d75862abea08
- 出典データセット
- uspto-grants-1992_03
- 特許番号
- US05093328
反応ノート
読み込み中…