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Hydrochloric Acid → 2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 3,5-Dichlorophenyl isocyanate | HCID 94460 | — |
| 反応物 | 2-(4-Aminophenoxy)-2-methylpropanoic acid | HCID 2774958 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid | HCID 195347 | — |
反応手順
To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182°-184°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05093367 |
| 出典データセット | uspto-grants-1992_03 |
| ORD ID | ord-8d94d8709c9f44a4915c2e7a75791515 |
| 出典メモ | uspto-grants-1992_03 |