diethyl 3,4-dihydro-7-[3-(4-chlorophenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoate → 3,4-dihydro-7-[3-(2-propylphenoxy)propoxy]-4-oxo-8-propyl-2H-1-benzopyran-2,2-dipropanoic acid
反応式
[CH2:1]([C:4]1[CH:42]=[CH:41][CH:40]=[CH:39][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:35]=[CH:34][C:14]2[C:15](=[O:33])[CH2:16][C:17]([CH2:26][CH2:27][C:28]([O:30]CC)=[O:29])([CH2:19][CH2:20][C:21]([O:23]CC)=[O:22])[O:18][C:13]=2[C:12]=1[CH2:36][CH2:37][CH3:38])[CH2:2][CH3:3].ClC1C=CC(OCCCOC2C=CC3C(=O)CC(CCC(OCC)=O)(CCC(OCC)=O)OC=3C=2CCC)=CC=1>>[CH2:1]([C:4]1[CH:42]=[CH:41][CH:40]=[CH:39][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:35]=[CH:34][C:14]2[C:15](=[O:33])[CH2:16][C:17]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[O:18][C:13]=2[C:12]=1[CH2:36][CH2:37][CH3:38])[CH2:2][CH3:3]参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared by the method of Example 22 substituting the title product of Example 40 (446 mg) for the title product of Example 21. Crystallization from ethyl acetate/hexane produced 252 mg as a solid, m.p. 163°-165° C.