2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile → 3-((((1,1-Dimethylethoxy)carbonyl)amino)methyl)benzeneacetic acid
反応式
Cl.[NH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=1.Cl.NCC1C=CC(CC(O)=O)=CC=1.[C:27]([O:31][C:32](ON=C(C1C=CC=CC=1)C#N)=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32]([NH:2][CH2:3][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)=[O:33])([CH3:30])([CH3:29])[CH3:28]参加物
4
実験手順
Substitution of an equivalent amount of 3-aminomethylphenylacetic acid hydrochloride for 4-aminomethylphenylacetic acid hydrochloride in the reaction with 2-t-butoxycarbonyloxyimino-2-phenylacetonitrile described in Example 54 gave 3-(N-t-butoxycarbonylaminomethyl)phenylacetic acid, m.p. 95°-96.5°.