化工社化工社 化学情報印刷レポート · 研究参考用
3-Methyl-DL-aspartic acid → N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methyl-DL-aspartic acid | HCID 852 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid | HCID 290744 | 100.8% |
反応手順
Using a similar method to above 3-methyl-D,L-aspartic acid (10.0 g, 67 mmol), benzyl chloroformate (12 ml, 100 mmol) in 50% NaOH (16.7 g, 208 mmol) in water (125 ml) yielded N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid 19.0g as a low melting solid. 1H NMR (90 MHz, CDCl3 /d6DMSO): δ1.1 (3,d), 2.9 (1,dt), 4.4 (1,m), 4.95 (2,s) 5.9 (1,bd) 7.2 (5,6) 7.9 (1,bs).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05095009 |
| 出典データセット | uspto-grants-1992_03 |
| ORD ID | ord-40ba4377061848d0aefb87629504ce54 |
| 出典メモ | uspto-grants-1992_03 |