2-Indanol → octahydro-1H-inden-2-ol

HRID 2371759ノート

反応式

HRID 2371759 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[OH:10]>CO.[Rh]>[CH2:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[OH:10]

参加物

4

反応物 1

HCID 779362-Indanol

生成物 1

HCID 12537367octahydro-1H-inden-2-ol

試薬・触媒・溶媒 2

HCID 23948Rhodium触媒HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

To a solution of 13.4 g (10.0 mmol) of 2-indanol in 100 mL of dry methanol was added 3.0 g of 5% Rh on carbon under a stream of argon. The solution was shaken in a Parr hydrogenation apparatus under hydrogen at 60 psi and 20° C. for 8 h. The mixture was filtered through Celite 545, rinsing with methanol, and the filtrate concentrated and distilled to give 4.2 g (30%) of (2 alpha and 2 beta 3a alpha, 7a alpha)-octahydro-1H-inden-2-ol, bp 130°-131° C. (18 mm); TLC Rf 0.68, 0.60 (SiO2, ethyl ether, molybdophosphoric acid-dark blue).

後処理

  1. filtrationThe mixture was filtered through Celite 545
  2. washrinsing with methanol
  3. concentrationthe filtrate concentrated
  4. distillationdistilled

出典と根拠

ORDレコード
ord-015bdb1ec98244fb8e4aa9708f509560
出典データセット
uspto-grants-1992_03
特許番号
US05095109

反応ノート

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