(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate → Tolterodine

HRID 237179

反応式

HRID 237179 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.C(O)(C(O)=O)C(O)C(O)=O>O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1

参加物

3

反応物 1

HCID 9847786(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate

生成物 1

HCID 443879Tolterodine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Tolterodine tartrate, microcrystalline cellulose and part of ethylcellulose are blended with small amount of water into homogeneous blend from which pellet cores are made by extrusion and spheronization. Dry pellet cores are coated with the coating dispersion of Example 8. Within first hour almost 50% dissolves, however between 7 and 16 hours less dissolves as compared to Example 2.

後処理

  1. customDry pellet cores
  2. dissolutionWithin first hour almost 50% dissolves, however between 7 and 16 hours
  3. dissolutionless dissolves

出典と根拠

ORDレコード
ord-cc18d6845501455995a9f42bb0d6eea0
出典データセット
uspto-grants-2014_02
特許番号
US08642078B2

関連ノート

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