Sodium Acetate → HCID 85114049、化合物

HRID 2372376ノート

反応式

HRID 2372376 の反応式
[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=[S:7])[CH:3]1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9].C([O-])(=O)C.[Na+].[CH2:19]([O:21][C:22](=[O:28])[CH2:23][C:24]([CH2:26]Br)=O)[CH3:20]>C(O)C>[CH:11]([O:10][C:8]([C:3]1[CH:2]([CH3:1])[CH2:6][N:5]2[C:24](=[CH:23][C:22]([O:21][CH2:19][CH3:20])=[O:28])[CH2:26][S:7][C:4]=12)=[O:9])([CH3:13])[CH3:12]

参加物

5

反応物 3

HCID 517045Sodium AcetateHCID 575284Ethyl 4-bromo-3-oxobutanoateHCID 10465433Isopropyl 4-Methyl-2-thioxopyrrolidine-3-carboxylate

生成物 1

HCID 85114049HCID 85114049、化合物収率 43.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4.9 g of isopropyl 4-methyl-2-thioxopyrrolidine-3-carboxylate was dissolved in 50 ml of ethanol and 3.0 g of anhydrous sodium acetate and 7.7 g of 4-bromoacetoacetic acid ethyl ester were added thereto. The obtained mixture was stirred at room temperature for 3.5 hours. The crystals thus precipitated were collected by filtration, washed with water and dried. After recrystallization from a mixture of chloroform and ethanol, 3.3 g of the title compound was obtained.

後処理

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization
  6. additionfrom a mixture of chloroform and ethanol

出典と根拠

ORDレコード
ord-4c9c4bb3448c45f98ce1ec299dad1ffc
出典データセット
uspto-grants-1992_03
特許番号
US05098919

反応ノート

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