Morpholine → HCID 67756016、化合物

反応式

[CH:1]([O:4][C:5]([C:7]1[C:8]([CH3:19])=[CH:9][N:10]2[CH:14]([CH2:15][C:16]([OH:18])=O)[CH2:13][S:12][C:11]=12)=[O:6])([CH3:3])[CH3:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.C1(N=C=NC2CCCCC2)CCCCC1>ClCCl>[CH:1]([O:4][C:5]([C:7]1[C:8]([CH3:19])=[CH:9][N:10]2[CH:14]([CH2:15][C:16]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[O:18])[CH2:13][S:12][C:11]=12)=[O:6])([CH3:2])[CH3:3]

参加物

実験手順

1.54 g of (7-isopropoxycarbonyl-6-methyl-2,3-dihydropyrrolo[2,1-b]thiazol-3-yl)acetic acid, 0.70 g of morpholine and 0.12 g of 4-N,N-dimethylaminopyridine were dissolved in 50 ml of dichloromethane. 1.44 g of N,N'-dicyclohexylcarbodiimide was added thereto under ice-cooling and stirring. Then the mixture was stirred at room temperature for 9 days. After filtering off the insoluble matters, the solvent was distilled off. The oily residue thus obtained was purified by silica gel column chromatography. After crystallizing from ether/n-hexane, 1.05 g of the title compound was obtained.