2-Ethyl-2-hydroxymethylbutan-1,3-diol → 3,3-Di-(hydroxymethyl)-1,1,1-trifluorohexan-2-ol

反応式

[CH2:1]([C:4]([C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])([C:10](OCC)=[O:11])[C:5](OCC)=[O:6])[CH2:2][CH3:3].C(C(CO)(C(O)C)CO)C>>[OH:6][CH2:5][C:4]([CH2:10][OH:11])([CH2:1][CH2:2][CH3:3])[CH:15]([OH:20])[C:16]([F:18])([F:19])[F:17]

参加物

反応物 2

HCID 129305482-Ethyl-2-hydroxymethylbutan-1,3-diol

HCID 15021952Diethyl 2-n-propyl-2-trifluoroacetylmalonate

生成物 1

HCID 150219533,3-Di-(hydroxymethyl)-1,1,1-trifluorohexan-2-ol

実験手順

3,3-Di-(hydroxymethyl)-1,1,1-trifluoro-hexan-2-ol was prepared from diethyl 2-n-propyl-2-trifluoroacetylmalonate using the method described for the preparation of 2-ethyl-2-hydroxymethyl-butan-1,3-diol [example A(ii)].

出典と根拠

ORDレコード: ord-d6765cb5eb5d44a4a0f9f5f2dde111b2
出典データセット: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05098929

反応ノート

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